Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery.

ABSTRACT: Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasall

SUBMITTER: Petersen LK 

PROVIDER: S-EPMC3693819 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature