Microarray gene expression profiling of neural tissues in bovine spastic paresis.

ABSTRACT:

Background

Bovine Spastic Paresis (BSP) is a neuromuscular disorder which affects both male and female cattle. BSP is characterized by spastic contraction and overextension of the gastrocnemious muscle of one or both limbs and is associated with a scarce increase in body weight. This disease seems to be caused by an autosomal and recessive gene, with incomplete penetration, although no genes clearly involved with its onset have been so far identified. We employed cDNA microarrays to identify metabolic pathways affected by BSP in Romagnola cattle breed. Investigation of those pathways at the genome level can help to understand this disease.

Results

Microarray analysis of control and affected individuals resulted in 268 differentially expressed genes. These genes were subjecte

SUBMITTER: Pariset L 

PROVIDER: S-EPMC3693873 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature