Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids.

ABSTRACT:

Background

Although a number of clinical and preclinical studies have demonstrated analgesic effects of cannabinoid treatments, there are also instances when cannabinoids have had no effect or even exacerbated pain. The observed pro-nociceptive effects appear to be due to cannabinoid-induced disinhibition of afferent synaptic input to nociceptive circuits. To better understand how cannabinoid-mediated plasticity can have both pro- and anti-nociceptive effects, we examined the possibility that cannabinoids differentially modulate nociceptive vs. non-nociceptive synapses onto a shared postsynaptic target. These experiments were carried out in the central nervous system (CNS) of the medicinal leech, in which it is possible to intracellularly record from presynaptic nociceptive (N-cell

SUBMITTER: Higgins A 

PROVIDER: S-EPMC3693973 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature