HASP server: a database and structural visualization platform for comparative models of influenza A hemagglutinin proteins.

ABSTRACT:

Background

Influenza A viruses possess RNA genomes that mutate frequently in response to immune pressures. The mutations in the hemagglutinin genes are particularly significant, as the hemagglutinin proteins mediate attachment and fusion to host cells, thereby influencing viral pathogenicity and species specificity. Large-scale influenza A genome sequencing efforts have been ongoing to understand past epidemics and pandemics and anticipate future outbreaks. Sequencing efforts thus far have generated nearly 9,000 distinct hemagglutinin amino acid sequences.

Description

Comparative models for all publicly available influenza A hemagglutinin protein sequences (8,769 to date) were generated using the Rosetta modeling suite. The C-alpha root mean square deviations between a rando

SUBMITTER: Ambroggio XI 

PROVIDER: S-EPMC3693987 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature