Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials.

ABSTRACT:

Background

Drug interactions can have a significant impact on the response to combinatorial therapy for anticancer treatment. In some instances these interactions can be anticipated based on pre-clinical models. However, the anticipation of drug interactions in the clinical context is in general a challenging task.

Methods

Here we propose the pooled analysis of clinical trials as a mean to investigate drug interactions in anticancer therapy. To this end we collected 1,163 Phase II clinical trials with response data on over 53,745 subjects.

Results

We provide statistical definitions of drugs resulting in clinical synergy and antagonism and identify drug combinations in each group. We also quantify the possibility of inferring interactions between three or more drugs fr

SUBMITTER: Kang W 

PROVIDER: S-EPMC3694030 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature