Automatic workflow for the classification of local DNA conformations.

ABSTRACT:

Background

A growing number of crystal and NMR structures reveals a considerable structural polymorphism of DNA architecture going well beyond the usual image of a double helical molecule. DNA is highly variable with dinucleotide steps exhibiting a substantial flexibility in a sequence-dependent manner. An analysis of the conformational space of the DNA backbone and the enhancement of our understanding of the conformational dependencies in DNA are therefore important for full comprehension of DNA structural polymorphism.

Results

A detailed classification of local DNA conformations based on the technique of Fourier averaging was published in our previous work. However, this procedure requires a considerable amount of manual work. To overcome this limitation we developed an au

SUBMITTER: Cech P 

PROVIDER: S-EPMC3694522 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature