Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model.

ABSTRACT:

Motivation

Combinatorial interactions of transcription factors with cis-regulatory elements control the dynamic progression through successive cellular states and thus underpin all metazoan development. The construction of network models of cis-regulatory elements, therefore, has the potential to generate fundamental insights into cellular fate and differentiation. Haematopoiesis has long served as a model system to study mammalian differentiation, yet modelling based on experimentally informed cis-regulatory interactions has so far been restricted to pairs of interacting factors. Here, we have generated a Boolean network model based on detailed cis-regulatory functional data connecting 11 haematopoietic stem/progenitor cell (HSPC) regulator genes.

Results

Despite its appare

SUBMITTER: Bonzanni N 

PROVIDER: S-EPMC3694641 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature