Poly(A) motif prediction using spectral latent features from human DNA sequences.

ABSTRACT:

Motivation

Polyadenylation is the addition of a poly(A) tail to an RNA molecule. Identifying DNA sequence motifs that signal the addition of poly(A) tails is essential to improved genome annotation and better understanding of the regulatory mechanisms and stability of mRNA. Existing poly(A) motif predictors demonstrate that information extracted from the surrounding nucleotide sequences of candidate poly(A) motifs can differentiate true motifs from the false ones to a great extent. A variety of sophisticated features has been explored, including sequential, structural, statistical, thermodynamic and evolutionary properties. However, most of these methods involve extensive manual feature engineering, which can be time-consuming and can require in-depth domain knowledge.

Results</

SUBMITTER: Xie B 

PROVIDER: S-EPMC3694652 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature