Dynamic excitatory and inhibitory gain modulation can produce flexible, robust and optimal decision-making.

ABSTRACT: Behavioural and neurophysiological studies in primates have increasingly shown the involvement of urgency signals during the temporal integration of sensory evidence in perceptual decision-making. Neuronal correlates of such signals have been found in the parietal cortex, and in separate studies, demonstrated attention-induced gain modulation of both excitatory and inhibitory neurons. Although previous computational models of decision-making have incorporated gain modulation, their abstract forms do not permit an understanding of the contribution of inhibitory gain modulation. Thus, the effects of co-modulating both excitatory and inhibitory neuronal gains on decision-making dynamics and behavioural performance remain unclear. In this work, we incorporate time-dependent co-modulation of th

SUBMITTER: Niyogi RK 

PROVIDER: S-EPMC3694816 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature