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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

ABSTRACT: We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.

SUBMITTER: Uguru GC 

PROVIDER: S-EPMC3694883 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

Uguru Gabriel C GC   Mondhe Madhav M   Goh Shan S   Hesketh Andrew A   Bibb Mervyn J MJ   Good Liam L   Stach James E M JE  

PloS one 20130627 6

We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces. ...[more]

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