The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors.

ABSTRACT: Human bocavirus is the second autonomous human parvovirus with assumed pathogenic potential. Other parvoviruses are known to persist and even integrate into the host genome, eventually contributing to the multi-step development of cancer. Human bocavirus also persists in an unknown percentage of clinically asymptomatic patients in addition to those with primary infection. The aim of the present study was to analyze the role of Human bocavirus in lung and colorectal cancers. Therefore, formalin-fixed, paraffin-embedded, archived tumor samples were screened for Human bocavirus DNA by PCR, Southern blotting, and sequencing. Positive tissues were further subjected to fluorescence in situ hybridization analysis to specifically detect human bocavirus DNA in the infected cells. In total, 11 of th

SUBMITTER: Schildgen V 

PROVIDER: S-EPMC3694905 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature