Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients.

ABSTRACT:

Background

The emergence and transmission of HIV-1 drug resistance (HIVDR) has raised concerns after rapid global antiretroviral therapy (ART) scale-up. There are limited data on the epidemiology of primary HIVDR in resource-limited settings in Asia. We aimed to determine the prevalence and compare the distribution of HIVDR in a cohort of ART-naïve Asian patients with recent and chronic HIV-1 infection.

Methods

Multicenter prospective study was conducted in ART-naïve patients between 2007 and 2010. Resistance-associated mutations (RAMs) were assessed using the World Health Organization 2009 list for surveillance of primary HIVDR.

Results

A total of 458 patients with recent and 1,340 patients with chronic HIV-1 infection were included in the analysis. The overall preva

SUBMITTER: Kiertiburanakul S 

PROVIDER: S-EPMC3694952 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature