Dataset Information

The Association between Leptin Level and Breast Cancer: A Meta-Analysis.

ABSTRACT:

Background

Contradictory results have been reported regarding the association between leptin level and breast cancer. Therefore, a meta-analysis was performed to investigate this issue.

Methods

Published literature from PubMed and the Chinese National Knowledge Infrastructure (CNKI) Database was retrieved. This study was performed based on different cases and control groups. The combined effect ([Formula: see text]) with 95% confidence interval (CI) was calculated using fixed-effects or random-effects model analysis.

Results

Overall, the mean serum leptin level of case groups was significantly higher than that of control groups. A) For 9 studies comparing breast cancer cases and healthy controls the combined effect [Formula: see text] was 0.58 with 95% CI (0.48, 0.68). B) For 4 studies comparing premenopausal breast cancer cases and healthy controls the [Formula: see text] was 0.32 (0.12, 0.52). C) For 5 studies comparing postmenopausal cases and healthy controls the [Formula: see text] was 0.65 (0.46, 0.84). D) For 4 studies comparing breast cancer cases and breast benign controls the [Formula: see text] was 0.38 (0.17, 0.59). E) For 2 studies comparing premenopausal breast cancer cases and breast benign controls the [Formula: see text] was 0.33 (-0.25, 0.91). F) For 6 studies comparing postmenopausal breast cancer cases and breast benign controls the [Formula: see text] was 0.39 (0.19, 0.60). G) For 4 studies comparing lymph node metastasis positive cases and negative controls the [Formula: see text] was 0.72 (0.45, 1.00). H) For 3 studies comparing breast benign cases and healthy controls the [Formula: see text] was 0.71 (0.41, 1.01).

Conclusion

This meta-analysis suggests that leptin level plays a role in breast cancer and has potential for development as a diagnostic tool.

SUBMITTER: Niu J

PROVIDER: S-EPMC3694967 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

The Association between Leptin Level and Breast Cancer: A Meta-Analysis.

Niu Jingping J Jiang Le L Guo Weiheng W Shao Liang L Liu Yi Y Wang Liqin L

PloS one 20130627 6

<h4>Background</h4>Contradictory results have been reported regarding the association between leptin level and breast cancer. Therefore, a meta-analysis was performed to investigate this issue.<h4>Methods</h4>Published literature from PubMed and the Chinese National Knowledge Infrastructure (CNKI) Database was retrieved. This study was performed based on different cases and control groups. The combined effect ([Formula: see text]) with 95% confidence interval (CI) was calculated using fixed-effe ...[more]

PMID: 23826274

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Project description:ImportanceA potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic.ObjectiveTo provide a comprehensive review of the literature on the association of meningioma with breast cancer, supported by a meta-analysis.Data sourcesA systematic PubMed search was performed up to April 2023 to identify articles on the association of meningioma with breast cancer. The following key words were used strategically: meningioma, breast cancer, breast carcinoma, association, relation.Study selectionAll studies reporting women diagnosed with meningioma and breast cancer were identified. The search strategy was not limited by study design or publication date but only included articles in English. Additional articles were identified via citation searching. Studies reporting a complete population of meningiomas or breast cancer patients throughout a specific study period and a proportion of patients with a second pathology could be used for the meta-analysis.Data extraction and synthesisData extraction was performed by 2 authors in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. Meta-analyses regarding both populations were performed using a random-effects model. Risk of bias was assessed.Main outcomes and measuresThe main measures were whether there was an increased prevalence of breast cancer in female patients with meningioma and whether there was an increased prevalence of meningioma in female patients with breast cancer.ResultsA total of 51 retrospective studies (case reports, case series, and cancer registry reports) describing 2238 patients with both diseases were identified; 18 studies qualified for prevalence analyses and meta-analysis. The random-effects meta-analysis (13 studies) revealed a significantly greater prevalence of breast cancer in female patients with meningioma than in the overall population (odds ratio [OR], 9.87; 95% CI, 7.31-13.32). Meningioma incidence in patients with breast cancer (11 studies) was greater than that in the baseline population; however, the difference according to the random-effects model was not statistically significant (OR, 1.41; 95% CI, 0.99-2.02).Conclusions and relevanceThis large systematic review and the meta-analysis on the association between meningioma and breast cancer found nearly 10-fold higher odds of breast cancer in female patients with meningioma compared with the general female population. These findings suggest that female patients with meningioma should be screened more intensively for breast cancer. Further research is required to identify the factors causing this association.

Dataset Information

The Association between Leptin Level and Breast Cancer: A Meta-Analysis.

Background

Methods

Results

Conclusion

Publications

The Association between Leptin Level and Breast Cancer: A Meta-Analysis.

Similar Datasets

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