Inclusion of genotype with fundus phenotype improves accuracy of predicting choroidal neovascularization and geographic atrophy.

ABSTRACT:

Purpose

The accuracy of predicting conversion from early-stage age-related macular degeneration (AMD) to the advanced stages of choroidal neovascularization (CNV) or geographic atrophy (GA) was evaluated to determine whether inclusion of clinically relevant genetic markers improved accuracy beyond prediction using phenotypic risk factors alone.

Design

Cohort study.

Participants

White, non-Hispanic subjects participating in the Age-Related Eye Disease Study (AREDS) sponsored by the National Eye Institute consented to provide a genetic specimen. Of 2415 DNA specimens available, 940 were from disease-free subjects and 1475 were from subjects with early or intermediate AMD.

Methods

DNA specimens from study subjects were genotyped for 14 single nucleotide polymorphi

SUBMITTER: Perlee LT 

PROVIDER: S-EPMC3695024 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature