Dyslipidemia links obesity to early cerebral neurochemical alterations.

ABSTRACT:

Objective

To examine the role of hypertension, hyperglycemia, and dyslipidemia in potentially accounting for obesity-related brain vulnerability in the form of altered cerebral neurochemistry.

Design and methods

Sixty-four adults, ages 40-60 years, underwent a health screen and proton magnetic resonance spectroscopy ((1) H MRS) of occipitoparietal gray matter to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI), and glutamate (Glu) relative to creatine (Cr). The causal steps approach and nonparametric bootstrapping were utilized to assess if fasting glucose, mean arterial pressure or peripheral lipid/lipoprotein levels mediate the relationship between body mass index (BMI) and cerebral neurochemistry.

Results

Higher BMI was significantly related to hi

SUBMITTER: Haley AP 

PROVIDER: S-EPMC3695042 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature