Does low and oscillatory wall shear stress correlate spatially with early atherosclerosis? A systematic review.

ABSTRACT: Low and oscillatory wall shear stress is widely assumed to play a key role in the initiation and development of atherosclerosis. Indeed, some studies have relied on the low shear theory when developing diagnostic and treatment strategies for cardiovascular disease. We wished to ascertain if this consensus is justified by published data. We performed a systematic review of papers that compare the localization of atherosclerotic lesions with the distribution of haemodynamic indicators calculated using computational fluid dynamics. The review showed that although many articles claim their results conform to the theory, it has been interpreted in different ways: a range of metrics has been used to characterize the distribution of disease, and they have been compared with a range of haemodynami

SUBMITTER: Peiffer V 

PROVIDER: S-EPMC3695746 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature