Moraxella catarrhalis uses a twin-arginine translocation system to secrete the β-lactamase BRO-2.

ABSTRACT:

Background

Moraxella catarrhalis is a human-specific gram-negative bacterium readily isolated from the respiratory tract of healthy individuals. The organism also causes significant health problems, including 15-20% of otitis media cases in children and ~10% of respiratory infections in adults with chronic obstructive pulmonary disease. The lack of an efficacious vaccine, the rapid emergence of antibiotic resistance in clinical isolates, and high carriage rates reported in children are cause for concern. Virtually all Moraxella catarrhalis isolates are resistant to β-lactam antibiotics, which are generally the first antibiotics prescribed to treat otitis media in children. The enzymes responsible for this resistance, BRO-1 and BRO-2, are lipoproteins and the mechanism by which they

SUBMITTER: Balder R 

PROVIDER: S-EPMC3695778 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature