Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome.

ABSTRACT:

Background

This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors.

Methods

The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory-II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels.

Results

Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for ag

SUBMITTER: Chirinos DA 

PROVIDER: S-EPMC3696025 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature