Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma.

ABSTRACT: Around 20% of meningiomas histologically benign may be clinically aggressive and recur. This strongly affects management of meningioma patients. There is a need to evaluate the potential aggressiveness of an individual meningioma. Additional criteria for better classification of meningiomas will improve clinical decisions as well as patient follow up strategy after surgery. The aim of this study was to determine the relationship between gene expression profiles and new metabolic subgroups of benign meningioma with potential clinical relevance. Forty benign and fourteen atypical meningioma tissue samples were included in the study. We obtained metabolic profiles by NMR and recurrence after surgery information for all of them. We measured gene expression by oligonucleotide microarray measure

SUBMITTER: Serna E 

PROVIDER: S-EPMC3696107 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature