Mechanisms of stroke after intracranial angioplasty and stenting in the SAMMPRIS trial.

ABSTRACT:

Background

Enrollment in the stenting and aggressive medical management for the prevention of stroke in intracranial stenosis (SAMMPRIS) trial was halted owing to higher-than-expected 30-day stroke rates in the stenting arm. Improvement in periprocedural stroke rates from angioplasty and stenting for intracranial atherosclerotic disease (ICAD) requires an understanding of the mechanisms of these events.

Objective

To identify the types and mechanisms of periprocedural stroke after angioplasty and stenting for ICAD.

Methods

Patients who experienced a hemorrhagic or ischemic stroke or a cerebral infarct with temporary signs within 30 days of attempted angioplasty and stenting in SAMMPRIS were identified. Study records, including case report forms, procedure notes, and im

SUBMITTER: Derdeyn CP 

PROVIDER: S-EPMC3696348 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature