Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome.

ABSTRACT:

Aim

Metabolic syndrome affects a large proportion of the population and increases cardiovascular disease risk. Because metabolic syndrome often co-exists clinically with atherosclerosis, it is difficult to distinguish the respective contributions of the components to vascular abnormalities. Accordingly, we utilized a porcine dietary model of metabolic syndrome without atherosclerosis to investigate early abnormalities of vascular function and signaling.

Methods

Thirty-two Yucatan micropigs were fed either a high-fat, high-simple-sugar, high-calorie (HFHS) or standard chow diet (STD) for 6 months. Neither diet contained added cholesterol. Blood pressure and flow-mediated vasodilatation were assessed at baseline and 6 months. Aortas were harvested at 6 months to assess histolo

SUBMITTER: Low Wang CC 

PROVIDER: S-EPMC3696427 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature