Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation.

ABSTRACT:

Objectives/hypothesis

Vestibular neuritis is a common cause of both acute and chronic vestibular dysfunction. Multiple pathologies have been hypothesized to be the causative agent of vestibular neuritis; however, whether herpes simplex type I (HSV1) reactivation occurs within the vestibular ganglion has not been demonstrated previously by experimental evidence. We developed an in vitro system to study HSV1 infection of vestibular ganglion neurons (VGNs) using a cell culture model system.

Study design

basic science study.

Results

Lytic infection of cultured rat VGNs was observed following low viral multiplicity of infection (MOI). Inclusion of acyclovir suppressed lytic replication and allowed latency to be established. Upon removal of acyclovir, latent infection was c

SUBMITTER: Roehm PC 

PROVIDER: S-EPMC3696486 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature