Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

ABSTRACT:

Background

Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease.

Methods

We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of significantly associated loci in an independent sample series. Estimates of population-attributable risk were calculated from estimates from the discovery and replication phases combined, and risk-profile estimates for loci identified in the discovery phase were calculated.

Findings

The discovery phase consisted of 5333 case and 12 019 control samples, with gen

SUBMITTER: International Parkinson Disease Genomics Consortium 

PROVIDER: S-EPMC3696507 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature