Hematologic responses in patients with aplastic anemia treated with deferasirox: a post hoc analysis from the EPIC study.

ABSTRACT: Reports are emerging of hematologic responses associated with iron chelation therapy; however, studies are limited in aplastic anemia patients. Deferasirox reduced iron overload in aplastic anemia patients enrolled in the EPIC (Evaluation of Patients' Iron Chelation with Exjade(®)) study (n=116). A post hoc analysis of hematologic responses was conducted on 72 patients with evaluable hematologic parameters (according to UK guideline criteria), 24 of whom received deferasirox without concomitant immunosuppressive treatment. Partial hematologic responses were observed in 11 of 24 (45.8%) patients; all became transfusion-independent. One patient had an additional platelet response and one patient had an additional platelet and hemoglobin response. Mean serum ferritin levels at end of study we

SUBMITTER: Lee JW 

PROVIDER: S-EPMC3696607 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature