Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.

ABSTRACT: The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of numerous NF-κB-induced immune response genes, including antimicrobial peptide genes. The IMD pathway shows significant similarities with the TNF receptor pathway. Recent evidence indicates that the IMD pathway is also activated in response to various noninfectious stimuli (i.e., inflammatory-like reactions). To gain a better understanding of the molecular machinery underlying the pleiotropic functions of this pathway, we first performed a comprehen

SUBMITTER: Fukuyama H 

PROVIDER: S-EPMC3696746 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature