Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear.

ABSTRACT: Traumatic events can engender persistent excessive fear responses to trauma reminders that may return even after successful treatment. Extinction, the laboratory analog of behavior therapy, does not erase conditioned fear memories but generates competing, fear-inhibitory "extinction memories" that, however, are tied to the context in which extinction occurred. Accordingly, a dominance of fear over extinction memory expression--and, thus, return of fear--is often observed if extinguished fear stimuli are encountered outside the extinction (therapy) context. We show that postextinction administration of the dopamine precursor L-dopa makes extinction memories context-independent, thus strongly reducing the return of fear in both mice and humans. Reduced fear is accompanied by decreased amygda

SUBMITTER: Haaker J 

PROVIDER: S-EPMC3696794 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature