Conserved microRNA pathway regulates developmental timing of retinal neurogenesis.

ABSTRACT: Most regions of the vertebrate central nervous system develop by the sequential addition of different classes of neurons and glia. This phenomenon has been best characterized in laminated structures like the retina and the cerebral cortex, in which the progenitor cells in these structures are thought to change in their competence as development proceeds to generate different types of neurons in a stereotypic sequence that is conserved across vertebrates. We previously reported that conditional deletion of Dicer prevents the change in competence of progenitors to generate later-born cell types, suggesting that specific microRNAs (miRNAs) are required for this developmental transition. In this report, we now show that three miRNAs, let-7, miR-125, and miR-9, are key regulators of the early t

SUBMITTER: La Torre A 

PROVIDER: S-EPMC3696811 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature