Study of the viral and microbial communities associated with Crohn's disease: a metagenomic approach.

ABSTRACT:

Objectives

This study aimed to analyze and compare the diversity and structure of the viral and microbial communities in fecal samples from a control group of healthy volunteers and from patients affected by Crohn's disease (CD).

Methods

Healthy adult controls (n=8) and patients affected by ileocolic CD (n=11) were examined for the viral and microbial communities in their feces and, in one additional case, in the intestinal tissue. Using two different approaches, we compared the viral and microbial communities in several ways: by group (patients vs. controls), entity (viruses vs. bacteria), read assembly (unassembled vs. assembled reads), and methodology (our approach vs. an existing pipeline). Differences in the viral and microbial composition, and abundance between the two

SUBMITTER: Perez-Brocal V 

PROVIDER: S-EPMC3696940 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature