Assessment of the value of a genetic risk score in improving the estimation of coronary risk.

ABSTRACT:

Background

The American Heart Association has established criteria for the evaluation of novel markers of cardiovascular risk. In accordance with these criteria, we assessed the association between a multi-locus genetic risk score (GRS) and incident coronary heart disease (CHD), and evaluated whether this GRS improves the predictive capacity of the Framingham risk function.

Methods and results

Using eight genetic variants associated with CHD but not with classical cardiovascular risk factors (CVRFs), we generated a multi-locus GRS, and found it to be linearly associated with CHD in two population based cohorts: The REGICOR Study (n=2351) and The Framingham Heart Study (n=3537) (meta-analyzed HR [95%CI]: ~1.13 [1.01-1.27], per unit). Inclusion of the GRS in the Framingham ris

SUBMITTER: Lluis-Ganella C 

PROVIDER: S-EPMC3697002 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature