ω-Transaminase from Ochrobactrum anthropi is devoid of substrate and product inhibitions.

ABSTRACT: ω-Transaminases display complicated inhibitions by ketone products and both enantiomers of amine substrates. Here, we report the first example of ω-transaminase devoid of such inhibitions. Owing to the lack of enzyme inhibitions, the ω-transaminase from Ochrobactrum anthropi enabled efficient kinetic resolution of α-methylbenzylamine (500 mM) even without product removal.

SUBMITTER: Park ES 

PROVIDER: S-EPMC3697560 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature