Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.

ABSTRACT: Numerous single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified by genome-wide association studies (GWAS). However, these SNPs were primarily discovered and validated in women of European and Asian ancestry. Because linkage disequilibrium is ancestry-dependent and heterogeneous among racial/ethnic populations, we evaluated common genetic variants at 22 GWAS-identified breast cancer susceptibility loci in a pooled sample of 1502 breast cancer cases and 1378 controls of African ancestry. None of the 22 GWAS index SNPs could be validated, challenging the direct generalizability of breast cancer risk variants identified in Caucasians or Asians to other populations. Novel breast cancer risk variants for women of African ancestry were identified

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC3697898 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature