Assessing genome-wide statistical significance for large p small n problems.

ABSTRACT: Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.

SUBMITTER: Diao G 

PROVIDER: S-EPMC3697980 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature