The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast.

ABSTRACT: The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.

SUBMITTER: Akiyoshi B 

PROVIDER: S-EPMC3697981 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature