Intraclonal genome diversity of Pseudomonas aeruginosa clones CHA and TB.

ABSTRACT:

Background

Adaptation of Pseudomonas aeruginosa to different living conditions is accompanied by microevolution resulting in genomic diversity between strains of the same clonal lineage. In order to detect the impact of colonized habitats on P. aeruginosa microevolution we determined the genomic diversity between the highly virulent cystic fibrosis (CF) isolate CHA and two temporally and geographically unrelated clonal variants. The outcome was compared with the intraclonal genome diversity between three more closely related isolates of another clonal complex.

Results

The three clone CHA isolates differed in their core genome in several dozen strain specific nucleotide exchanges and small deletions from each other. Loss of function mutations and non-conservative amino acid r

SUBMITTER: Bezuidt OK 

PROVIDER: S-EPMC3697988 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature