Interfacing cellular networks of S. cerevisiae and E. coli: connecting dynamic and genetic information.

ABSTRACT:

Background

In recent years, various types of cellular networks have penetrated biology and are nowadays used omnipresently for studying eukaryote and prokaryote organisms. Still, the relation and the biological overlap among phenomenological and inferential gene networks, e.g., between the protein interaction network and the gene regulatory network inferred from large-scale transcriptomic data, is largely unexplored.

Results

We provide in this study an in-depth analysis of the structural, functional and chromosomal relationship between a protein-protein network, a transcriptional regulatory network and an inferred gene regulatory network, for S. cerevisiae and E. coli. Further, we study global and local aspects of these networks and their biological information overlap by co

SUBMITTER: de Matos Simoes R 

PROVIDER: S-EPMC3698017 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature