Proteomic profiling for the identification of serum diagnostic biomarkers for abdominal and thoracic aortic aneurysms.

ABSTRACT:

Background

Aortic aneurysm is an increasingly common vascular disorder with fatal implication. However, there is no established diagnosis other than that based on aneurysmal size. For this purpose, serum protein biomarkers for aortic aneurysms are valuable. Although most of the studies on serum biomarker discovery have been based on comparison of serum proteins from the patient group with those from the healthy group, we considered that comparison of serial protein profiles such as those in presurgical and postsurgical sera within one patient would facilitate identification of biomarkers since the variability of serial protein profiles within one patient is smaller than that between groups. In this study, we examined serum proteins with differential levels in postsurgery compared w

SUBMITTER: Satoh K 

PROVIDER: S-EPMC3698092 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature