Use of mixed-treatment-comparison methods in estimating efficacy of treatments for heavy menstrual bleeding.

ABSTRACT:

Background

A variety of pharmacological and surgical treatments have been developed for heavy menstrual bleeding (HMB), which can have negative physical, social, psychological, and economic consequences. We conducted a systematic literature review and mixed-treatment-comparison (MTC) meta-analysis of available data from randomized controlled trials (RCTs) to derive estimates of efficacy for 8 classes of treatments for HMB, to inform health-economic analysis and future studies.

Methods

A systematic review identified RCTs that reported data on menstrual blood loss (MBL) at baseline and one or more follow-up times. Eight treatment classes were considered: COCs, danazol, endometrial ablation, LNG-IUS, placebo, progestogens given for less than 2 weeks out of 4 during the menstrua

SUBMITTER: Hoaglin DC 

PROVIDER: S-EPMC3698104 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature