Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.

ABSTRACT:

Background

The CD14 C-159T single nucleotide polymorphism (SNP) has been investigated widely as a candidate genetic locus in patients with allergic disease. There are conflicting results for the association of the CD14 C-159T SNP with total serum immunoglobulin E (IgE) levels and atopy. There are limited data regarding the association of the CD14 C-159T SNP in subjects of African ancestry. The aim of the study was to determine whether the C-159T SNP and other CD14 SNPs (C1188G, C1341T) were associated with total serum IgE levels and with allergy skin test results in nonatopic and atopic subjects; as well as in Caucasian and African American subjects.

Methods

A total of 291 participants, 18-40 years old, were screened to determine whether they were atopic and/or asthmatic. An

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3699133 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature