Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.

ABSTRACT:

Background

Accurate determination of genetic ancestry is of high interest for many areas such as biomedical research, personal genomics and forensics. It remains an important topic in genetic association studies, as it has been shown that population stratification, if not appropriately considered, can lead to false-positive and -negative results. While large association studies typically extract ancestry information from available genome-wide SNP genotypes, many important clinical data sets on rare phenotypes and historical collections assembled before the GWAS area are in need of a feasible method (i.e., ease of genotyping, small number of markers) to infer the geographic origin and potential admixture of the study subjects. Here we report on the development, application and limit

SUBMITTER: Nievergelt CM 

PROVIDER: S-EPMC3699392 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature