Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis.

ABSTRACT:

Background

Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagnosis of gastric cancer.

Methods

A systematic review and meta-analysis was performed to evaluate the overall accuracy of CTCs detection for diagnosing gastric cancer. PubMed, Embase and the Wanfang database were searched in all languages published up to Oct 2012. The pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR, respectively), diagnostic odds ratio (DOR) and summary receiver operating characteristic (sROC) curve were calculated to evaluate the overall test performance.

Results

Twenty studies were incl

SUBMITTER: Tang L 

PROVIDER: S-EPMC3699416 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature