Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors.

ABSTRACT:

Background

Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. Increased arterial stiffness could be the link between the 9p21 polymorphism and increased cardiovascular risk. Since the impact of a genetic polymorphism on arterial stiffness especially in Asian populations has not been well defined, we aimed to investigate the association of arterial stiffness with rs 1333049 variant on chromosome 9p21.3 in Thai subjects with and without MetS risk factors.

Methods

A total of 208 Thai subjects, aged 35-7

SUBMITTER: Phababpha S 

PROVIDER: S-EPMC3699419 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature