Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach.

ABSTRACT: We provide comprehensive identification of embryonic (E15) and adult rat lateral ventricular choroid plexus transcriptome, with focus on junction-associated proteins, ionic influx transporters and channels. Additionally, these data are related to new structural and previously published permeability studies. Results reveal that most genes associated with intercellular junctions are expressed at similar levels at both ages. In total, 32 molecules known to be associated with brain barrier interfaces were identified. Nine claudins showed unaltered expression, while two claudins (6 and 8) were expressed at higher levels in the embryo. Expression levels for most cytoplasmic/regulatory adaptors (10 of 12) were similar at the two ages. A few junctional genes displayed lower expression in embryos,

SUBMITTER: Liddelow SA 

PROVIDER: S-EPMC3699566 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature