Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement.

ABSTRACT:

Background

Previous studies have demonstrated that endothelial progenitor cells (EPCs), in particular late EPCs, play important roles in endothelial maintenance and repair. Recent evidence has revealed shear stress as a key regulator for EPC differentiation. However, the underlying mechanisms regulating the shear stress-induced EPC differentiation have not been understood completely. The present study was undertaken to further investigate the effects of shear stress on the late EPC differentiation, and to elucidate the signal mechanism involved.

Methodology/principal finding

In vitro and in vivo assays revealed that cytoskeletal remodeling was involved in the shear stress-upregulated expression of endothelial markers vWF and CD31 in late EPCs, with subsequently increased in

SUBMITTER: Cheng M 

PROVIDER: S-EPMC3699607 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature