Predicting and analyzing interactions between Mycobacterium tuberculosis and its human host.

ABSTRACT: The outcome of infection by Mycobacterium tuberculosis (Mtb) depends greatly on how the host responds to the bacteria and how the bacteria manipulates the host, which is facilitated by protein-protein interactions. Thus, to understand this process, there is a need for elucidating protein interactions between human and Mtb, which may enable us to characterize specific molecular mechanisms allowing the bacteria to persist and survive under different environmental conditions. In this work, we used the interologs method based on experimentally verified intra-species and inter-species interactions to predict human-Mtb functional interactions. These interactions were further filtered using known human-Mtb interactions and genes that are differentially expressed during infection, producing 190 in

SUBMITTER: Rapanoel HA 

PROVIDER: S-EPMC3699628 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature