Platinum-based chemotherapy for variant castrate-resistant prostate cancer.

ABSTRACT:

Purpose

Clinical features characteristic of small-cell prostate carcinoma (SCPC), "anaplastic," often emerge during the progression of prostate cancer. We sought to determine the efficacy of platinum-based chemotherapy in patients meeting at least one of seven prospectively defined "anaplastic" clinical criteria, including exclusive visceral or predominantly lytic bone metastases, bulky tumor masses, low prostate-specific antigen levels relative to tumor burden, or short response to androgen deprivation therapy.

Experimental design

A 120-patient phase II trial of first-line carboplatin and docetaxel (CD) and second-line etoposide and cisplatin (EP) was designed to provide reliable clinical response estimates under a Bayesian probability model with early stopping rules in pla

SUBMITTER: Aparicio AM 

PROVIDER: S-EPMC3699964 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature