Concordance rates of birth defects after assisted reproductive technology among 17 258 Japanese twin pregnancies: a nationwide survey, 2004-2009.

ABSTRACT:

Background

Most twins after assisted reproductive technology (ART) are dizygotic. Analysis of dizygotic twin pairs is useful in assessing familial aggregation in the development of birth defects.

Methods

Using nationwide post-ART data from the Japan Society of Obstetrics and Gynecology, recurrence risk ratios (RRRs)-defined as probandwise concordance rates of birth defects in twins divided by the prevalence of birth defects in the general population-were calculated as indicators of familial aggregation. Birth defects were then reclassified according to the ICD-10 categories corresponding to codes Q00-Q99. From 2004 to 2009, there were 17 258 twin pregnancies.

Results

At least 1 birth defect was noted in 236 twin pairs: 11 concordant and 225 discordant pairs. Regarding

SUBMITTER: Ooki S 

PROVIDER: S-EPMC3700233 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature