Body mass index and weight change during adulthood are associated with increased mortality from liver cancer: the JACC Study.

ABSTRACT:

Background

We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese.

Methods

The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009.

Results

During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95%CI, 1.07-3.54) for BMI less than 18.5 kg/m

SUBMITTER: Li Y 

PROVIDER: S-EPMC3700251 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature