Systems biology approaches for discovering biomarkers for traumatic brain injury.

ABSTRACT: The rate of traumatic brain injury (TBI) in service members with wartime injuries has risen rapidly in recent years, and complex, variable links have emerged between TBI and long-term neurological disorders. The multifactorial nature of TBI secondary cellular response has confounded attempts to find cellular biomarkers for its diagnosis and prognosis or for guiding therapy for brain injury. One possibility is to apply emerging systems biology strategies to holistically probe and analyze the complex interweaving molecular pathways and networks that mediate the secondary cellular response through computational models that integrate these diverse data sets. Here, we review available systems biology strategies, databases, and tools. In addition, we describe opportunities for applying this meth

SUBMITTER: Feala JD 

PROVIDER: S-EPMC3700463 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature