The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis.

ABSTRACT:

Unlabelled

In advanced cirrhosis, impaired function is caused by intrinsic damage to the native liver cells and from the abnormal microenvironment in which the cells reside. The extent to which each plays a role in liver failure and regeneration is unknown. To examine this issue, hepatocytes from cirrhotic and age-matched control rats were isolated, characterized, and transplanted into the livers of noncirrhotic hosts whose livers permit extensive repopulation with donor cells. Primary hepatocytes derived from livers with advanced cirrhosis and compensated function maintained metabolic activity and the ability to secrete liver-specific proteins, whereas hepatocytes derived from cirrhotic livers with decompensated function failed to maintain metabolic or secretory activity. Telomere

SUBMITTER: Liu L 

PROVIDER: S-EPMC3700584 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature