Dynamic responses of Bacteroides thetaiotaomicron during growth on glycan mixtures.

ABSTRACT: Bacteroides thetaiotaomicron (Bt) is a human colonic symbiont that degrades many different complex carbohydrates (glycans), the identities and amounts of which are likely to change frequently and abruptly from meal-to-meal. To understand how this organism reacts to dynamic growth conditions, we challenged it with a series of different glycan mixtures and measured responses involved in glycan catabolism. Our results demonstrate that individual Bt cells can simultaneously respond to multiple glycans and that responses to new glycans are extremely rapid. The presence of alternative carbohydrates does not alter response kinetics, but reduces expression of some glycan utilization genes as well as the cell's sensitivity to glycans that are present in lower concentration. Growth in a mixture cont

SUBMITTER: Rogers TE 

PROVIDER: S-EPMC3700664 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature